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Several multi-targeting agonists at GIPR, GLP-1R or GCGR, developed to maximize metabolic benefits with reduced side-effects, are in clinical trials to treat type 2 diabetes and obesity

Lilly and other followers will need to generate their own evidence to support cardiovascular benefits of their own obesity treatments to compete on coverage and use

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But with high monthly costs, fastchanging utilization, and longterm budget impact, the lowestcost option on paper doesnt always deliver the best results