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By the time most people reach their fifties, their average daily GH secretion is a fraction of what it was at twenty-five and with it, the downstream signalling that supports muscle maintenance, fat metabolism, and sleep architecture all shift accordingly

not simply a number on the scale
A single night of poor sleep causes acute rises in ghrelin levels, but leptin concentrations remain essentially the same

2012;18(7):BR286-91

Although not exclusive to diabetes related foot ulcers, they were chosen as reasonable proxies to capture delayed wound healing
