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It is important not to confuse early appetite reduction with the medication failingthis is the intended first phase of action

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Monitor weight loss rate: Whilst tirzepatide is effective for weight reduction, a gradual and steady approach (typically 0.51 kg per week) is generally better tolerated and less likely to disrupt hormonal balance than very rapid weight loss

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Efficacy differences: In the SURMOUNT-5 trial, tirzepatide achieved ~20% weight loss vs

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CT heterozygotes: ~65% activity

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Whether you get semaglutide from MedVi (compounded) or Ro (brand-name Wegovy), the most common side effects are the same: nausea, constipation, diarrhea, stomach pain, and decreased appetite

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