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[cited 2025 Nov 20]

[DOI] [PubMed] [Google Scholar] 98.Kelly R.P., Garhyan P., Raddad E., Fu H., Lim C.N., Prince M.J., Pinaire J.A., Loh M.T., Deeg M.A

they are receptor agonists, meaning that they work by binding to the GLP-1 receptors in the brain and body

In all observational studies, GLP-1 RAs were used as adjuncts to standard IIH care with nearly all patients also receiving acetazolamide

The mean rate of eGFR decline was -1.4 per year in the combined tirzepatide groups and -3.6 per year in the insulin group (between-group difference 2.2 [95% CI 1.6 to 2.8]) with a greater benefit in participants with eGFR 500mg/dl the use of bile acid sequestrants is contraindicated (424)