when did glp 1 come out Glucagon-like peptide-1 receptor: mechanisms and advances in therapy History of GLP-1: From Discovery

Moreover, liraglutide treatment significantly decreased IL-6, PGE 2 and nitric oxide secretion, and the expression of inflammatory genes in vitro in chondrocytes and macrophages in a dose-dependent manner

Animal studies have linked it to less weight gain, lower cholesterol levels, and improved inflammation

To put that in perspective, this level of weight reduction is comparable to what can be seen after some forms of bariatric surgery, but achieved through a peptide-based therapy

Kim M, Kim SC, Kim J, Kim BH

Int J Biol Sci 17(8):20502068 Bonfioli GB, Rodella L, Metra M, Vizzardi E (2024) GLP-1 receptor agonists as promising anti-inflammatory agents in heart failure with preserved ejection fraction