zepbound glp-1 Study flags need to monitor frailty risks with drugs for older adults Taking a GLP-1? Doctors say

Long-acting derivatives of glucagon like peptide-1 the endocrine society ENDO poster P2-45 15 RehfeldJ

Given the natural fluctuations in hormone levels and the intricate rhythms of human physiology throughout the day and over a persons lifetime, there is concern about the uncertain health ramifications of sustained elevation of incretin activity over decades of treatment

The cohort excludes any person with no diagnosis, procedure, or pharmacy claims of any kind in the prior 12 months for stability

Moral of the story

Your skin acts as a protective barrier, and even if small amounts of these compounds did get absorbed, research doesnt support that they would have any appetite-suppressing effects