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Updated with TRIUMPH-1 and TRANSCEND-T2D-1 Phase 3 data presented at the ADA 86th Scientific Sessions (June 2026)
Chronic knockdown of LH GLP-1R induced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA construct was sufficient to markedly and persistently elevate ingestive behavior and body weight and ultimately resulted in a doubling of fat mass in males and females
