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Home Wirkstoffgruppen Glucagon-like peptide 1 (GLP-1-)Rezeptoragonisten (Inkretinmimetika) werden zur Behandlung von Diabetes mellitus Typ 2 in Kombination mit anderen Antidiabetika oder als Monotherapie, wenn Metformin nicht indiziert ist, eingesetzt
Peptide drugs are mainly eliminated by protease enzymes, while liver uptake is minimal

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Despite these setbacks, encouraging animal data warrant future efforts for the development of new drugs capable to activate synergistically both GPR40 and GPR120 and mediate, through GLP-1 and other intestinal, pancreatic and cerebral peptides, better treatments for multifactorial chronic metabolic diseases
