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You should be advised to: Report any new neck swelling or changes in voice Monitor for symptoms of thyroid dysfunction (either hypo- or hyperthyroidism) Maintain consistent timing of levothyroxine administration Keep a record of weight changes Report severe or persistent gastrointestinal symptoms Stay well-hydrated, especially if experiencing nausea, vomiting or diarrhoea Medication adherence to both levothyroxine and GLP-1 therapy is essential for optimal outcomes

Animal studies on GLP-1RAs in NAFLD A selection of available animal studies evaluating the effects of different GLP-1RAs on NAFLD is presented in Table 1 and is briefly discussed herein

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Beyond enzymatic breakdown, the intestinal mucus layer poses another significant barrier