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This led researchers to wonder if GIP agonists would even work in the population that needed them most

Salcedo I, Tweedie D, Li Y, Greig NH

Interestingly, we discovered that the risk of hypoglycemia caused by tirzepatide was reduced when it was administered without insulinotropic drugs or insulin [10]

The mechanism of action involves several physiological effects: GLP-1 receptor agonists stimulate insulin secretion in a glucose-dependent manner, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways

The low placental transfer could be caused by the release of Dipeptidyl peptidase IV positive syncytiotrophoblast-derived extracellular vesicles released by the human placenta which degrade GLP-1 in uterine blood (63), as well as to the high molecular weight of GLP-1 agonists (4 73 kDa)