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It commonly occurs at: Asparagine residues Glutamine residues Key Analytical Challenges Very small mass shifts Formation of structural isomers Complex chromatographic separation Similar fragmentation behavior Because deamidated species may closely resemble the native peptide, advanced peptide mapping and high-resolution MS strategies are essential for accurate differentiation

These results indicate a potential risk in the use semaglutide in NENs expressing GLP-1R

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Despite its high global prevalence, peripheral artery disease (PAD) remains frequently underdiagnosed and undertreated, constituting a critical residual CV risk factor and a clinical accelerator of major adverse cardiac events (MACE), major adverse limb events (MALE), and cerebrovascular disease