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Despite these concerns, including side effects like gastrointestinal issues, pancreas inflammation, and gallbladder problems, these drugs remain widely used for weight loss

The absence of leg cramps from official labeling does not definitively rule out a connection, as post-marketing experience sometimes reveals adverse effects not detected in pre-approval trials due to sample size limitations, duration of follow-up, or patient population differences

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Boxed warning (class): avoid with medullary thyroid carcinoma (MTC) or MEN2 history

For those who have existing problems with severe depression and suicidal ideation, its important to pay careful attention to changes in mood when starting any medication, including GLP-1 drugs, Ueda said