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For instance, blood sugar fluctuations in elderly diabetics were identified as a significant factor affecting white matter density (Tamura et al., 2017)

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Authorea [PREPRINT] 2025;4:2325

This phenomenon is further illustrated by results from a randomized, open-label mechanistic trial in patients with T2DM, which demonstrated that lixisenatide, with a half-life of 2 4 hours, had a significantly greater effect than liraglutide in delaying in gastric emptying and curtailing postprandial glucose excursions following a standardized solid breakfast (156)