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With GLP-1 drugs widely available via direct-to-consumer websites and, increasingly, directly from drug manufacturers, most adults who have taken these medications say they got them from their primary health care provider or a specialist (76%), while about one in six (17%) report getting them from an online provider or website

Funding MB and KI are part funded by the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and Kings College London

After SCI, the loss of advanced central control of the sympathetic nerve, the destruction of intestinal immune homeostasis, the impairment of intestinal barrier function, inflammation and the use of antibiotics will lead to the imbalance of intestinal microbiota and further cause gastrointestinal dysfunction

They regulate blood sugar, reduce hunger, and increase feelings of fullness, making them a powerful tool for weight loss

But for others, especially those with a sensitive digestive system, the impact on gut movement can be significant