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As patients lose weight and improve glycemic control, alterations in insulin sensitivity, leptin levels, and other metabolic hormones could potentially affect taste perception

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The medium was then discarded and replaced with fresh medium containing insulin at concentrations of 2, 50, and 1250 nM or ITP at concentrations of 1.25, 2.5, 5, and 10 M

This drug has been shown to cause significant body weight loss and is already in clinical use [27]