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The adverse health effects of obesity itself are so dire that, like bariatric surgery, one could argue that these weight-loss drugs should be considered as a last resort, but there are diet and lifestyle changes that can naturally restore our GLP-1 satiety circuits

This makes it possible to assess whether a dose adjustment is sufficient, whether another treatment would be more appropriate, or whether treatment should be discontinued

[1] [9] In the central nervous system, these medications act on appetite-regulating centers to reduce hunger and increase satiety, contributing to weight loss

Lifestyle changes in women with polycystic ovary syndrome

Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes