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they also suppress platelet activity, which may further contribute to cardiovascular protection ( 3.4 Complications and side effects of GLP-1 RAs Common side effects associated with GLP-1 receptor agonists (GLP-1 RAs) include gastrointestinal symptoms such as nausea (2560%), diarrhea, and vomiting (515%) ( While some studies have suggested a possible association between GLP-1 RAs and acute kidney injury (AKI), this has not been confirmed and appears to occur primarily in patients with underlying risk factors such as dehydration or severe gastrointestinal symptoms ( GLP-1 RA therapy should be discontinued under specific clinical conditions to minimize risk

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In line with this finding, a recent study has shown that MOTS-c also regulates alanine, aspartate and glutamate metabolism in the liver 88

Also important are questions that explore diabetes control, symptoms that suggest hypothyroidism, history of previous surgery and medications (Tables 4, 5)