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Metformin combined with heavy alcohol use raises the risk of lactic acidosis
Oduori OS, Murao N, Shimomura K, Takahashi H, Zhang Q, Dou H, et al
Cardiovascular and renal outcome trials reporting outcomes on GLP-1RA, SGLT-2 inhibitors and DPP-4 inhibitors in patients with or without type 2 diabetes mellitus were included

Ben explains the progression: The first GLP-1 molecule discovered was liraglutide, which has a 13 to 15-hour active life
