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FDA approved for chemotherapy-induced, postoperative, radiation therapy-associated nausea and vomiting

Retatrutide targets GLP-1, GIP, and glucagon receptors for comprehensive metabolic action Phase 2 trials showed up to 24% body weight loss over 48 weeks in participants The medication is administered as a once-weekly injection, similar to existing treatments Eli Lilly is developing Retatrutide, with Phase 3 trials currently underway UK availability is not expected until at least 2026-2027 following regulatory approval Weight Loss Treatment Comparison Calculator Estimate potential weight loss based on current clinical trial data for different medications Based on average clinical trial results

This hormone signals by binding to and activating GCGR, which is a G protein-coupled receptor primarily expressed by hepatocytes in the liver

As the substudy included only 29% of the sample of the main study (98 of 338 participants), the starting dose subgroups for the 4 mg and 8 mg treatment arms were pooled for analyses in this substudy