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A realistic earliest FDA decision window, assuming Phase 3 confirms the Phase 2 findings, is 2028

Therefore, there should be a reasonable effort to design alternative short-chain peptide-based GLP-1RAs with low toxicity and efficacy comparable to marketed long-chain peptides

Is there a natural alternative to tirzepatide that actually works
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CREB-dependent transcription, possibly altering the synthesis of secretory proteins or ion transporters that regulate saliva composition

The GLP1R rs6923761 Gly168Ser variant is associated with reduced receptor efficacy and appears in a proportion of non-responders
