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In PD, the underlying pathological is an injury to the dopaminergic projections from the substantia nigra pars compacta to the caudate nucleus and putamen (striatum) [175]

For some patients, particularly those with specific comorbidities or medication combinations, a provider may recommend semaglutide as the more clinically appropriate choice

However, individual results may vary, and side effects should be considered when choosing between the two

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It is imperative to approach Semaglutide with a full understanding of its safety profile