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Also, the researchers were not able to verify the participants self-reported alcohol intake, and roughly one-third of them were not available for follow-up

Most were mild to moderate and tended to occur during dose increases, similar to the pattern seen with semaglutide and tirzepatide.[1] A finding worth flagging: in the obesity trial, retatrutide produced small increases in heart rate (about 5 to 7 beats per minute on average at the higher doses).[1] Heart rate increases have also been seen with other drugs in this class, but the size in retatrutide was on the higher end

According to the manufacturer of semaglutide, the concentration of the drug in the bloodstream typically reaches a steady level after 45 weeks of once-weekly use

Drug Interactions 9.1 Interaction with Oral Antidiabetic Medications (Sulfonylureas, Metformin) 9.2 Risk of Hypoglycemia with Insulin Co-administration 9.3 Impact on Absorption of Oral Drugs Due to Delayed Gastric Emptying 9.4 Interaction with Weight Loss Medications 9.5 Alcohol Interaction and Glycemic Variability 9.6 Potential Interactions with Cardiovascular Drugs 10