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Ultimately, the decision between simultaneous initiation and sequential add-on therapy should be individualized, considering patient-specific factors such as comorbidities, baseline kidney function, and treatment goals

Additionally, the product is easier to teach patients to use, making it easier to initiate necessary treatment early.

GLP-1RAs directly enhance NK cell cytotoxicity, promote DC antigen presentation, and ameliorate the immunosuppressive microenvironment by inhibiting NET formation and regulating macrophage polarization, thereby offering novel perspectives for combination immunotherapy

In keeping with recommendations issued by NICE, the FDA, and various other obesity experts, GLP-1s are often administered in tandem with holistic, multidisciplinary behavioural and lifestyle interventions, such as counselling, progress monitoring, and peer support

Mechanisms of GLP-1 receptor agonist-induced weight loss: a review of central and peripheral pathways in appetite and energy regulation
