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Thereafter, the observation of incretin activity after the inactivation of GIP suggested the existence of other molecules with an incretin effect

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[7] Tirzepatide is administered as a once-weekly subcutaneous injection, starting at 2.5 mg for 4 weeks as an initiation dose before titrating to maintenance doses of 5-15 mg depending on the indication and patient tolerance

doi: 10.1038/mp.2017.187 [DOI] [PMC free article] [PubMed] [Google Scholar] Lu J, Zou S, Liu X, Wong TYP, Zhang X, Xu KS, Zhao Y, Hong Y, Cen A, Wang Y