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Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance

Considering that PPG neurons are projecting neurons that have axons containing GLP1 vesicles in many distinct regions of the brain (Figure 1), it seems likely that GLP1 release and action within the brain is locally restricted and regulated like that of other neurotransmitters and modulators

A larger decrease in systolic blood pressure was observed with retatrutide vs

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This suggests that GLP-1R mice may serve as a model of correlated metabolic-functional connectivity changes in the brain