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This is novel compared to older agents that targeted just one pathway

DEG upon ingestion is promptly absorbed and distributed to well-perfused organs and metabolized to a toxic metabolite in the liver

While the primary disease processes occur in the brain, transcriptomic data from MCI brain tissue are not available, as brain samples are typically collected postmortem from advanced AD cases

Analysis: Bronya Calvarysky, Yaara Gal, Shiri Kushnir, Adi Turjeman, Tzippy Shochat, Idit Dotan and Talia Diker Cohen

Oral semaglutide 25mg achieved average weight loss of 16.6% at 64 weeks, while orforglipron 36mg achieved 12.4% at 72 weeks