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LY3437943, a Novel Triple GIP/GLP-1/Glucagon Receptor Agonist, Shows Glucose-Lowering and Body Weight-Lowering Efficacy After Single-Dose Administration in Type 2 Diabetes Patients

Such lipotoxicity induces cardiotoxic effects through bioactive sphingolipids like ceramides and diacylglycerols (DAGs) (82)

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Generally, a drug is considered short-acting if its blood concentration declines before the next dose and long-acting if its pharmacologic effects persist until the subsequent dose