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Effects of GLP-1 agonists on vascular endothelium Enhancing endothelial function A review of the literature revealed multiple preclinical studies on GLP-1R agonists in animal models demonstrating the molecular mechanisms behind their pharmacological effects

In a rodent model of NASH, 3-week treatment with glucagon/T 3 lowered ALT levels and improved macroscopic and histological features of NASH, including reversal of fibrosis (82)

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GLP-1R belongs to the family of G-protein-coupled receptors (GPCRs), which play a crucial role in transmitting signals across cell membranes