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Table 1 shows the characteristics of the GLP-1 receptor agonist-SGLT-2 inhibitor combination users and GLP-1 receptor agonist users after matching

Important safety considerations include a boxed warning regarding thyroid C-cell tumors observed in rodents (though the relevance to humans is unknown) and contraindications for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

For nonadherence, the 1year absolute risks of nonadherence stratified according to baseline HbA1c are shown in Figure S1B

However, there is considerable criticism around the ability to cancel and being locked in without a way out

Patients experience more fluid walking and less freezing on stairs or during long walks