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Discussion Most animal studies demonstrated a beneficial effect of GLP-1RAs and related peptide polyagonists on LFTs, glucose, and lipid metabolism and, most importantly, on hepatic steatosis and inflammation (Tables 1 and 2)

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Semaglutide is generally cost-effective for T2D management, but results vary by region, sponsor, and model assumptions, emphasizing the need for transparent, context-sensitive economic evaluations

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