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The Institute for Clinical and Economic Review (ICER) in 2025 noted that price reductions and long-term benefits have improved GLP-1 cost-effectiveness relative to older assumptions ( [70] ), yet insurers still face high absolute spend

This series of changes is mainly driven by a significant reduction in the expression of the key transcriptional coactivator, peroxisome proliferator-activated receptor coactivator 1 (PGC-1)