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Some studies suggest certain probiotic strains can modestly increase postprandial GLP-1 levels in controlled settings
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Additionally, blockade of GLP-1Rs in the LS with exendin-9 alone enhanced sucrose and oil intake indicating a physiologic role for these neurons to suppress food intake

The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes

Daily GLP-1 medications present a different set of timing considerations
