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Semaglutide is different in that, even though it increases insulin levels, you lose weight

EMBO Rep (2006) 7(9):8805.10.1038/sj.embor.7400779 117 BertolottiAWangXNovoaIJungreisRSchlessingerKChoJHet alIncreased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

Some people reported weight loss after 2 weeks of use, with continued weight loss over several months

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In a vast majority of the patients I see here are having a lot of multifactorial reasons for their weight problems, and they need that medication long term to continue to preserve that weight loss that they've had great success with," Cohen said