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Moderate calorie restriction combined with gradual, supervised exercise has been shown to preserve milk supply in most women

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Mean body weight reduction at 48 weeks was 1.6% for placebo, 8.7% for 1mg, 17.3% for 4mg, 22.8% for 8mg, and 24.2% for 12mgdose-dependent escalation with the highest dose surpassing tirzepatide's 22.5% at 72 weeks in the SURMOUNT-1 trial