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The mechanisms by which GLP-1 RAs induce weight loss are multifaceted and are linked to GLP-1R activation in both central and peripheral enteric neurons, slowing gastric emptying and intestinal transit, as well as suppressing appetite at the hypothalamus level, collectively influencing a mechanism known as the ileal brake

As for its role in protein synthesis, tryptophan is a precursor of crucial metabolites, such as 5-HT, which plays an essential role in functional gastrointestinal diseases (Heitkemper et al., 2016)

12 February 2026

[DOI] [Google Scholar] 75.Taher M., Abdul Majid F.A., Sarmidi M.R

Yang S, Zhao L, Mi Y, He W
