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[15] [6] Whilst GLP-1 receptor agonists are generally well-tolerated, they can produce various side effects

It is important to note that receptor desensitization, feedback suppression, and compensatory signaling are by no means unique to peptidesthese phenomena are well documented for small-molecule drugs, including beta-blockers, opioids, and statins

All of these studies are hypothesis-generating and await confirmation in RCTs. According to Lane, the rationale for GLP-1 receptor agonists in lupus stems from the drugs demonstrating anti-inflammatory properties, potentially by inhibiting the NF-B pathway, which plays a crucial role in inflammation

Our study suggests that semaglutide may have bone protective effects despite its effect on weight loss, explained Kim

Understanding unapproved use of approved drugs "off label." Retrieved from Wharton, S., Freitas, P., Hjelmesth, J., et al