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The physiological basis of functional hyperaemia (see Glossary) is thought to reflect a vasoactive effect on the brain capillaries by the local accumulation of metabolic by-products during synaptic activity (e.g., lactate, CO 2 , H + ) and/or the active generation of vasodilatory mediators (e.g., NOnitric oxide, adenosine, ATP, K + ) [106,110,111]

Exenatide-induced depression in a geriatric patient

The development of gut hormone dual- and triagonists holds promise for treating obesity and T2DM with a level of effectiveness comparable to bariatric surgery

doi: 10.1007/s00125-024-06144-1

doi: 10.1007/s11126-025-10137-7 [DOI] [PubMed] [Google Scholar] 30