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The label advises healthcare providers to consider discontinuing the medication if these symptoms occur and recommends caution when using Zepbound in patients with a history of suicidal attempts or ideation

Eur Hear J Cardiovasc Pharmacother

Further supporting the role of Pax6 in regulating intestinal Gcg expression, adenoviral overexpression of Pax6 enhances Gcg promoter activity and Gcg expression in intestinal enteroendocrine cells such as the secretin tumor cell line-1 (STC-1) and cells derived from colonic tumors of transgenic mice expressing large T antigen under the control of the proglucagon promoter (GLUTag cells) [108]