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It has been shown that glucagon release can be inhibited by activating the mitogen-activated protein kinase pathway, enhancing the transcription of Paired Box 6 and Proglucagon genes, and further promoting the production of GLP-1 and activation of GLP-1R in -cells ( in vivo (Saltiel and Kahn, 2001

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Statements Author contributions JW: Writing original draft, Writing review & editing