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Taken together, such evidence strengthens the argument that tirzepatide should carry an explicit warning for bowel obstruction as a potential adverse effect, particularly given its increasing use in diabetes and obesity management

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Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists

3638 In nervous system Finally, in the central nervous system, GLP-1RAs regulate appetite and energy balance by binding to GLP-1R in key brain regions, particularly the hypothalamus and brainstem

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