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Given the high prevalence of fatty liver in diabetic patients (estimated at 5570%), initiating or switching to a GLP-1 agonist addresses both conditions simultaneously

With branded products commanding having experienced intermittent supply constraints, compounding pharmacies stepped in to fill the gapoperating under Section 503A of the Federal Food, Drug, and Cosmetic Act, which exempts qualifying compounders from certain FDA requirements, including CGMP compliance, labeling requirements, and premarket approval

Pros: Superior weight loss results, multireceptor approach Cons: Phase II clinical trials, awaiting FDA approval Semaglutide FDA-approved for weight loss, semaglutide offers up to 15%-20% weight loss

Biochem Biophys Res Commun 423:583587 Garibay D, McGavigan AK, Lee SA et al (2016) -cell glucagon-like peptide-1 receptor contributes to improved glucose tolerance after vertical sleeve gastrectomy