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Diabetes Obes Metab 2010;12:384-92.ArticlePubMedPMC 136

Examples include high blood pressure, prediabetes, type 2 diabetes, sleep apnea, high cholesterol, and cardiovascular disease

Constant or intermittent

Sleep 28 , 9981004 (2005)

Because common GI side effects like nausea, constipation, and fatigue are often related to dose size, starting with a lower dose may help reduce the chances of feeling uncomfortable