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Retrieved 10 April 2022

GLP-1RAs aid in weight loss by regulating the gut-brain axis and interacting with leptin, while weight loss can alleviate the harmful effects of obesity on the body, particularly in knee OA, by reducing joint loading and inflammation

1.5 Rationale and objectives of the review Building on the mechanistic and therapeutic frameworks established in see sections 1.3 The gut-ovary axis: a new frontier in PCOS pathophysiology and 1.4 Metformin and probiotics: two ointerventions cnverging on the gut, the recognition of the gutovary axis and the established roles of both metformin and probiotics provide a compelling rationale for their combined use

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Foster Goss, DO, MMSc, FACEP, an adjunct professor and site principal investigator for this study at the University of Colorado Anschutz Department of Emergency Medicine, co-authored a research letter on the study, published recently in JAMA Health Forum
