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Concerns include reports of adverse events, some requiring hospitalization, that may be related to dosing errors or doses beyond what is in the FDA-approved drug label, which means using more product in a single dose, taking doses more frequently or increasing the amount more quickly (titration schedule)

Peak plasma concentrations in humans of dulaglutide were reported as 114 ng/ml (about 2 nM, Geiser et al

This matters for safety and efficacy

Liraglutide Increases Bone Formation and Inhibits Bone Resorption in Rats with Glucocorticoid-Induced Osteoporosis

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