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This was observed even after controlling for weight loss, suggesting a direct joint-protective effect

Additionally, if diarrhea lasts more than a week, its important to reach out to your doctor

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To this end, Chen et al., has suggested that activation of GLP-1R with liraglutide could protect chondrocytes against endoplasmic reticulum (ER) stress, apoptosis and inflammation by decreasing the release of inflammatory mediators and regulating phosphoinositide 3-kinase (PI3K)/AKT signaling, which suggests that GLP-1R is a therapeutic target for the treatment of OA and that liraglutide could be a therapeutic candidate for clinical application [10]
