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In the subgroup analyses, human GLP-1 RAs, but not nonhuman GLP-1 RAs, reduced the risk of MACE in patients with HF ( p interaction = 0.11)

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These results indicate that GLP1RAs have therapeutic effects against EndMT, an important process in atherosclerosis and fibrotic diseases

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The other drawback is vial longevity

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Gastric bypass increases postprandial insulin and GLP-1 in nonobese minipigs

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