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Thomas and colleagues at Eli Lilly and Company, [76] investigate the impact of tirzepatide on beta-cell function and insulin sensitivity in individuals with type 2 diabetes

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According to the FDA prescribing information, tirzepatide is associated with modest increases in heart rate (average 2-4 beats per minute), consistent with the class effect observed with GLP-1 receptor agonists

Dinitrophenol was introduced in 1933, which uncoupled oxidative phosphorylation in the mitochondria to produce heat instead of ATP

16,47,96 Studies on animals indicate possible fetal damage, including death and birth abnormalities, as well as prospective problems, including growth restriction and preterm birth
