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GLP-1 increases heart rate despite cervical vagotomy, autonomic ganglion blockade, and HCN channel blockade Next, we evaluated if the parasympathetic nervous system, or the combined autonomic nervous system, is involved in the GLP-1-induced increase in heart rate
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Here we therefore report only the five more recent and inclusive reviews that summarize such evidence

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It has FDA approval, a well-characterized safety profile, and proven efficacy for its specific target
Springer, R., & Patel, R