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Cardio and protein matter, but if we had to prioritize, lifting weights changes physiology in ways that resistance training uniquely supports especially when someone is using appetite-suppressing medications or is at risk for sarcopenia

Further exploration of doseresponse relationships, long-term maintenance strategies, and the potential preventive role of GLP-1 RAs in high-risk populations (e.g., insulin-resistant youth with depressive symptoms) will be key to translating preliminary findings into clinical practice

The potential causes of this heterogeneity mainly include population characteristics, drug specificity, the intensity of lifestyle intervention, and the impact of comorbidities [50]

The prevalence of obesity has increased rapidly in recent years, doubling since 1980

Yusta B, Baggio LL, Koehler J, Holland D, Cao X, Pinnell LJ, Johnson-Henry KC, Yeung W, Surette MG, Bang KW