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This uncoupling effect is additionally suggested by a clinical study in Japanese patients with T2D in which significantly fewer patients treated with placebo on a background SU therapy (with or without other oral therapies) experienced hypoglycaemia than patients treated with exenatide BID and background SU (10 and 54%, respectively

105 ), the immature innate immune system in neonates has a low capacity to generate ROS, so pro-oxidative processes in neonatal sepsis are limited to intracellular compartments of affected tissues